Architecture firm Holmes Miller has filed an application for planning in principle to Glasgow City Council.
The hotel, which would be five storeys, would be based on London Road outside the main stand of Celtic Park and close to the Emirates Arena.
A restaurant as well as a cafe/bar would be on the ground floor of the building.
The proposed new shop, ticketing facility and museum entrance would be at first floor level with the main portion of the museum below this.
The Scottish Premiership champions hope to get the green light in the autumn.
Previous plans for a £44 million hotel development on a site facing Celtic Park were shelved in 2013.
A statement submitted with the new plans said: “The proposed development will result in the creation of some 100 to 120 permanent full and part-time jobs and will contribute positively to the regeneration of the Clyde Gateway area.”
The statement continued: “The direct creation of over 100 new employment opportunities will be a major boost to the area and will clearly contribute towards the key planning aim of achieving sustainable economic growth.
“There is currently no quality hotel accommodation within the area between the city centre and Tollcross despite the key attractions of Celtic Park and the Emirates Arena.
“The current lack of hotel accommodation in the vicinity means that everyone attending events at the football stadium or the arena requires to travel on the day of the event, adding to traffic volumes in the surrounding area.”
It added: “By locating the proposed hotel immediately beside the stadium and arena pressure on the local transport network will be reduced, particularly at times of peak movement.
“Experience elsewhere also demonstrates that hotel restaurant and cafe/bar facilities adjoining a football stadium can help to spread the timing of trips over a greater time period avoiding peak periods.”